Monocytosis and Lymphocytosis are Risk Factors of Dengue Hemorrhagic Fever in Children

Dengue infection with its broad clinical spectrum remains a health problem in Indonesia. An aberrant immune response in plasma leakage of dengue hemorrhagic fever (DHF) caused by increases of monocytes and lymphocytes.

The aim of this study was to investigate that monocytosis and lymphocytosis were risk factor of DHF in children. A case control study was conducted at Child Health Department Hasan Sadikin General Hospital, Bandung, from April to June, 2009. 

Children aged ≤14 years who fulfilled the clinical criteria for dengue fever (DF) and dengue hemorrhagic fever (DHF), according to WHO (1997) confirmed with serologic test.  Monocytes and lymphocytes count were measured on admission. 

Data were analyzed using chi square test, Mann-Whitney test, and  multiple logistic regression. The best cut-off point was determined using receiver operator characteristic (ROC) curve. All statistical computations were perfomed using SPSS 17.0 for Windows software.

There were 50 DF and 50 DHF. The mean level of monocytes for DF and DHF patients were 95.16/mm3 and 215.87/mm3; p1,472/mm3. Odds ratio (OR) of monocytosis (confidence interval 95%) was 6.55; p=0.011 and OR of lymphocitosis (confidence interval 95%) was 43.76; p<0,001.

If monocytosis was present, risk of DHF was 6.55 and lymphocytosis was present, risk of DHF was 43.76. It is concluded that monocytosis and lymphocytosis are risk factors of DHF in children.

Source : http://www.mkb-online.org/index.php?option=com_content&view=article&id=274:monositosis-dan-limfositosis-merupakan-faktor-risiko-demam-berdarah-dengue-pada-anak&catid=1:kumpulan-artikel&Itemid=55